\[ \int \frac {\left (a d e+\left (c d^2+a e^2\right ) x+c d e x^2\right )^{5/2}}{(d+e x)^{15/2}} \, dx \]
Optimal antiderivative \[ -\frac {5 c d \left (a d e +\left (a \,e^{2}+c \,d^{2}\right ) x +c d e \,x^{2}\right )^{\frac {3}{2}}}{24 e^{2} \left (e x +d \right )^{\frac {9}{2}}}-\frac {\left (a d e +\left (a \,e^{2}+c \,d^{2}\right ) x +c d e \,x^{2}\right )^{\frac {5}{2}}}{4 e \left (e x +d \right )^{\frac {13}{2}}}+\frac {5 c^{4} d^{4} \arctan \left (\frac {\sqrt {e}\, \sqrt {a d e +\left (a \,e^{2}+c \,d^{2}\right ) x +c d e \,x^{2}}}{\sqrt {-a \,e^{2}+c \,d^{2}}\, \sqrt {e x +d}}\right )}{64 e^{\frac {7}{2}} \left (-a \,e^{2}+c \,d^{2}\right )^{\frac {3}{2}}}-\frac {5 c^{2} d^{2} \sqrt {a d e +\left (a \,e^{2}+c \,d^{2}\right ) x +c d e \,x^{2}}}{32 e^{3} \left (e x +d \right )^{\frac {5}{2}}}+\frac {5 c^{3} d^{3} \sqrt {a d e +\left (a \,e^{2}+c \,d^{2}\right ) x +c d e \,x^{2}}}{64 e^{3} \left (-a \,e^{2}+c \,d^{2}\right ) \left (e x +d \right )^{\frac {3}{2}}} \]
command
integrate((a*d*e+(a*e^2+c*d^2)*x+c*d*e*x^2)^(5/2)/(e*x+d)^(15/2),x, algorithm="giac")
Giac 1.9.0-11 via sagemath 9.6 output
\[ \frac {{\left (\frac {15 \, c^{5} d^{5} \arctan \left (\frac {\sqrt {{\left (x e + d\right )} c d e - c d^{2} e + a e^{3}}}{\sqrt {c d^{2} e - a e^{3}}}\right ) e}{\sqrt {c d^{2} e - a e^{3}} {\left (c d^{2} - a e^{2}\right )}} - \frac {{\left (15 \, \sqrt {{\left (x e + d\right )} c d e - c d^{2} e + a e^{3}} c^{8} d^{11} e^{4} - 45 \, \sqrt {{\left (x e + d\right )} c d e - c d^{2} e + a e^{3}} a c^{7} d^{9} e^{6} + 55 \, {\left ({\left (x e + d\right )} c d e - c d^{2} e + a e^{3}\right )}^{\frac {3}{2}} c^{7} d^{9} e^{3} + 45 \, \sqrt {{\left (x e + d\right )} c d e - c d^{2} e + a e^{3}} a^{2} c^{6} d^{7} e^{8} - 110 \, {\left ({\left (x e + d\right )} c d e - c d^{2} e + a e^{3}\right )}^{\frac {3}{2}} a c^{6} d^{7} e^{5} + 73 \, {\left ({\left (x e + d\right )} c d e - c d^{2} e + a e^{3}\right )}^{\frac {5}{2}} c^{6} d^{7} e^{2} - 15 \, \sqrt {{\left (x e + d\right )} c d e - c d^{2} e + a e^{3}} a^{3} c^{5} d^{5} e^{10} + 55 \, {\left ({\left (x e + d\right )} c d e - c d^{2} e + a e^{3}\right )}^{\frac {3}{2}} a^{2} c^{5} d^{5} e^{7} - 73 \, {\left ({\left (x e + d\right )} c d e - c d^{2} e + a e^{3}\right )}^{\frac {5}{2}} a c^{5} d^{5} e^{4} - 15 \, {\left ({\left (x e + d\right )} c d e - c d^{2} e + a e^{3}\right )}^{\frac {7}{2}} c^{5} d^{5} e\right )} e^{\left (-4\right )}}{{\left (c d^{2} - a e^{2}\right )} {\left (x e + d\right )}^{4} c^{4} d^{4}}\right )} e^{\left (-4\right )}}{192 \, c d} \]
Giac 1.7.0 via sagemath 9.3 output
\[ \text {Timed out} \]________________________________________________________________________________________