\[ \int \frac {\left (a d e+\left (c d^2+a e^2\right ) x+c d e x^2\right )^{5/2}}{(d+e x)^{13/2}} \, dx \]
Optimal antiderivative \[ -\frac {5 c d \left (a d e +\left (a \,e^{2}+c \,d^{2}\right ) x +c d e \,x^{2}\right )^{\frac {3}{2}}}{12 e^{2} \left (e x +d \right )^{\frac {7}{2}}}-\frac {\left (a d e +\left (a \,e^{2}+c \,d^{2}\right ) x +c d e \,x^{2}\right )^{\frac {5}{2}}}{3 e \left (e x +d \right )^{\frac {11}{2}}}+\frac {5 c^{3} d^{3} \arctan \left (\frac {\sqrt {e}\, \sqrt {a d e +\left (a \,e^{2}+c \,d^{2}\right ) x +c d e \,x^{2}}}{\sqrt {-a \,e^{2}+c \,d^{2}}\, \sqrt {e x +d}}\right )}{8 e^{\frac {7}{2}} \sqrt {-a \,e^{2}+c \,d^{2}}}-\frac {5 c^{2} d^{2} \sqrt {a d e +\left (a \,e^{2}+c \,d^{2}\right ) x +c d e \,x^{2}}}{8 e^{3} \left (e x +d \right )^{\frac {3}{2}}} \]
command
integrate((a*d*e+(a*e^2+c*d^2)*x+c*d*e*x^2)^(5/2)/(e*x+d)^(13/2),x, algorithm="giac")
Giac 1.9.0-11 via sagemath 9.6 output
\[ \frac {{\left (\frac {15 \, c^{4} d^{4} \arctan \left (\frac {\sqrt {{\left (x e + d\right )} c d e - c d^{2} e + a e^{3}}}{\sqrt {c d^{2} e - a e^{3}}}\right ) e}{\sqrt {c d^{2} e - a e^{3}}} - \frac {{\left (15 \, \sqrt {{\left (x e + d\right )} c d e - c d^{2} e + a e^{3}} c^{6} d^{8} e^{3} - 30 \, \sqrt {{\left (x e + d\right )} c d e - c d^{2} e + a e^{3}} a c^{5} d^{6} e^{5} + 40 \, {\left ({\left (x e + d\right )} c d e - c d^{2} e + a e^{3}\right )}^{\frac {3}{2}} c^{5} d^{6} e^{2} + 15 \, \sqrt {{\left (x e + d\right )} c d e - c d^{2} e + a e^{3}} a^{2} c^{4} d^{4} e^{7} - 40 \, {\left ({\left (x e + d\right )} c d e - c d^{2} e + a e^{3}\right )}^{\frac {3}{2}} a c^{4} d^{4} e^{4} + 33 \, {\left ({\left (x e + d\right )} c d e - c d^{2} e + a e^{3}\right )}^{\frac {5}{2}} c^{4} d^{4} e\right )} e^{\left (-3\right )}}{{\left (x e + d\right )}^{3} c^{3} d^{3}}\right )} e^{\left (-4\right )}}{24 \, c d} \]
Giac 1.7.0 via sagemath 9.3 output
\[ \text {Timed out} \]________________________________________________________________________________________